Persistence of HPV in women treated for cervical adenocarcinoma

Telma Maria Lubambo Costa, Aline Pereira Morais, Adria Lins Gonçalves, Marina Maria Souto Valadares, Natalia Lumbambo Costa, Gustavo Fonseca de Albuquerque Souza, Paulo Roberto Eleutério Souza, Alex Sandro Souza

Abstract


Objective: to determine the frequency of persistence of HPV in women treated for cervical adenocarcinoma. Method: this is a quantitative, descriptive, retrospective, cohort study, with 77 women genotyped for HPV before treatment and with cervical adenocarcinoma. New cervical secretion material was collected after treatment to detect HPV DNA by polymerase chain reaction. The Epi Info 7.1.4 statistical program was used for data analysis. Results: it was observed that, out of 77 patients, it was possible to determine HPV genotyping after treatment in 30 women, and of these, seven (23.3%) had detectable HPV. HPV types were found, of which four patients (57.1%) had HPV 31, and in one patient it was associated with HPV 18; o 33 in two women (28.6%), one of whom was associated with HPV 16 and one had HPV 11 and 56 associated (14.2%). Conclusion: HPV was detected in cervical secretion in 23.3% of women after treatment for cervical adenocarcinoma, with HPV 31 being the most frequent type. Descriptors: Adenocarcinoma; Papillomaviridae; Treatment Failure; Prevalence; Cervix Uteri; Sexually Transmitted Diseases.

Resumo

Objetivo: determinar a frequência da persistência do HPV em mulheres tratadas para o adenocarcinoma cervical. Método: trata-se de um estudo quantitativo, descritivo, retrospectivo, do tipo coorte, com 77 mulheres genotipadas para o HPV antes do tratamento e com adenocarcinoma cervical. Coletou-se novo material de secreção cervical após o tratamento para a realização da detecção do DNA do HPV por reação de cadeia da polimerase. Utilizou-se o programa estatístico Epi Info 7.1.4. para a análise dos dados. Resultados: observou-se que, das 77 pacientes, foi possível determinar a genotipagem do HPV após o tratamento em 30 mulheres e, destas, 7 (23,3%) apresentaram o HPV detectável. Encontraram-se os tipos de HPV dos quais quatro pacientes (57,1%) estavam com o HPV 31, sendo que, em uma paciente, estava associado ao HPV 18; o 33 em duas mulheres (28,6%), sendo que em uma estava associado ao HPV 16 e uma apresentou os HPV 11 e 56 associados (14,2%). Conclusão: detectou-se o HPV na secreção cervical em 23,3% das mulheres após o tratamento para o adenocarcinoma de colo uterino, sendo o HPV 31 o tipo mais frequente. Descritores: Adenocarcinoma; HPV; Falha de Tratamento; Prevalência; Colo do Útero; Doenças Sexualmente Transmissíveis. 

Resumen

Objetivo: determinar la frecuencia de persistencia del VPH en mujeres tratadas por adenocarcinoma cervical. Método: estudio de cohorte cuantitativo, descriptivo, retrospectivo, con 77 mujeres genotipadas para el VPH antes del tratamiento y con adenocarcinoma cervical. Se recogió nuevo material de secreción cervical después del tratamiento para detectar el ADN del VPH por reacción en cadena de la polimerasa. Se utilizó el programa estadístico Epi Info 7.1.4. para el análisis de datos. Resultados: se observó que, de las 77 pacientes, fue posible determinar el genotipo del VPH después del tratamiento en 30 mujeres, y de estos, 7 (23.3%) tenían VPH detectable. Se encontraron tipos de VPH, de los cuales cuatro pacientes (57.1%) tenían VPH 31, y en una paciente se asoció con VPH 18; o 33 en dos mujeres (28,6%), una de las cuales estaba asociada con el VPH 16 y una tenía VPH 11 y 56 (14,2%). Conclusión: el VPH se detectó en la secreción cervical en el 23,3% de las mujeres después del tratamiento para el adenocarcinoma de cuello uterino, siendo el VPH 31 el tipo más frecuente. Descriptores: Adenocarcinoma; Papillomaviridae; Insuficiencia del Tratamiento; Prevalencia; Cuello del Útero; Enfermedades de Transmisión Sexual.


Keywords


Adenocarcinoma; Papillomaviridae; Treatment Failure; Prevalence; Cervix Uteri; Sexually Transmitted Diseases.

References


Bruni L, Albero G, Serrano B, Mena M, Gómez D, Muñoz J, et al. ICO/IARC Information Centre on HPV and Cancer (HPV Information Centre). Human Papilloma virus and Related Diseases in the World. Summary Report [Internet]. Barcelona: ICO/IARC HPV Information Centre; 2019 [cited 2020 Jan 17]. Available from: https://www.hpvcentre.net/statistics/reports/XWX.pdf

Carmen MG, Schorge J. Cervical adenocarcinoma in situ. UpToDate [Internet]. 2019 Aug [cited 2019 Dec 23]. Available from: https://www.uptodate.com/contents/cervical-adenocarcinoma-in-situ

Santos JA, Sousa R, Coelho MC, Sá JL. Cervical adenocarcinoma in situ: factors associated with residual lesion after cone biopsy. Acta Obstet Ginecol Port [Internet]. 2017 Mar [cited 2019 Oct 08];11(1):22-7. Available from: http://www.scielo.mec.pt/scielo.php?script=sci_arttext&pid=S1646-58302017000100004&lng=pt.

Horst JVD, Siebers AG, Bulten J, Massuger LF, Kok IMCM. Increasing incidence of invasive and in situ cervical adenocarcinoma in the Netherlands during 2004–2013. Cancer Med. 2017 Feb;6(2):416-23. DOI: 10.1002/cam4.971

Ntzeros K, Thomakos N, Sotiropoulou M, Papapanagiotou I, Rodolakis A, Loutradis D. Adenocarcinoma in situ of the uterine cervix and the value of conservative management. Eur J Obstet Gynecol Reprod Biol. 2019 Mar; 234:e43. DOI: 10.1016/j.ejogrb.2018.08.248

Santos MO. Estimativa 2018: incidência do câncer no Brasil. Rev Bras Cancerol [Internet]. 2018 May [cited 2019 Aug 10];64(1):119-20. Available from: http://www1.inca.gov.br/rbc/n_64/v01/pdf/15-resenha-estimativa-2018-incidencia-de-cancer-no-brasil.pdf

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015 Mar;136(5):e359-86. DOI: 10.1002/ijc.29210

Sousa AMV, Teixeira CCA, Medeiros SS, Nunes SJC, Salvador PTCO, Barros RMB, et al. Cervical cancer mortality in the state of Rio Grande do Norte, Brazil, 1996-2010: time trends and projections up to 2030. Epidemiol Serv Saúde. 2016 June;25(2):311-22. DOI: 10.5123/s1679-49742016000200010.

Céspedes N, Aparicio C. Depression and quality of life in women with cervical cancer at the Regional Hospital of Encarnación. Rev Nac (Itauguá). 2017;9(2):32-45. DOI: 10.18004/rdn2017.0009.02.046-066

Kfouri CFA, Lombardi W, Romania MCFN, Puls ML, Martins-Ferreira RA, Lombardi LB, et al. Prognostic factors for response to chemotherapy in advanced tumors of the uterine cervix: the role of neoangiogenesis. Rev Col Bras Cir. 2019 Feb;46(1):e2077. DOI: 10.1590/0100-6991e-20192077

Stratton P, Battiwalla M, Tian X, Abdelazim S, Baird K, Barrett AJ, et al. Immune response following quadrivalent human papillomavirus vaccination in women after hematopoietic allogeneic stem cell transplant: a nonrandomized clinical trial. JAMA Oncol. 2020 Feb. DOI: 10.1001/jamaoncol.2019.6722

Abbas KM, van Zandvoort K, Brisson M, Jit M. Effects of updated demography, disability weights, and cervical cancer burden on estimates of human papillomavirus vaccination impact at the global, regional, and national levels: a PRIME modelling study. The Lancet. 2020 Feb. DOI: 10.1016/S2214-109X(20)30022-X.

Costa TML, Heráclio S, Amorim MMR, Souza PRE, Lubambo N, Souza GFA, et al. Human papillomavirus and risk factors for cervical adenocarcinoma in the state of Pernambuco, Brazil. Rev Bras Saude Mater Infant. 2019 July/Sept;19(3):641-9. DOI: 10.1590/1806-93042019000300009

Rangel G, Lima LD, Vargas EP. Conditioning factors in the late diagnosis of cervical cancer from the perspective of women treated at Inca. Saúde Debate. 2015 Oct/Dec;39(107):1065-78. DOI: 10.1590/0103-110420161070261

Rezende LFM, Arnold M, Rabacow FM, Levy RB, Claro RM, Giovannucci E, et al. The increasing burden of cancer attributable to high body mass index in Brazil. Cancer Epidemiol. 2018 June;54:63-70. DOI: 10.1016/j.canep.2018.03.006

Guedes DS, Carvalho AZFT, Lima ICV, Cunha GH, GalvãoMTG, Farias OO. Vulnerability of women with human immunodeficiency virus to cervical cancer. Esc Anna Nery Rev Enferm. 2019 Apr;23(2):20180203. DOI: 10.1590/2177-9465-ean-2018-0203

Muentes GDG, Rodríguez LKG, Galarraga RIB, Carpio FA, Cabezas JCR. Genotypes distribution of human papillomavirus in cervical samples of Ecuadorian women. Rev Bras Epidemiol. 2016 Jan/Mar; 19(1):160-6. DOI: 10.1590/1980-5497201600010014

Silva DSM, Silva AMN, Brito LMO, Gomes SRL, Nascimento MDSB, Chein MBC. Cervical cancer screening in the State of Maranhão, Brazil. Ciênc Saúde Colet. 2014 Apr;19(4):1163-70. DOI: 10.1590/1413-81232014194.00372013

Singh U, Verma ML, Rahman Z, Qureshi S, Srivastava K. Factors affecting quality of life of cervical cancer patients: a multivariate analysis. J Can Res Ther. 2019 Oct/Dec;15(6):1338-44. DOI: 10.4103/jcrt.JCRT_1028_17

Araújo AF, Castro Júnior AR, Freitas MC, Pereira MLD, Rodrigues DP, Torres RAM, et al. Young people in web radio: social representations about human Papillomavirus. J Nurs UFPE on line. 2019;13:e239855 DOI: 10.5205/1981-8963.2019.239855




DOI: https://doi.org/10.5205/1981-8963.2020.244212



Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

INDEXADORES E BASES BIBLIOGRÁFICAS:

doajPeriódicoscapes

bvs elsevier nlm diadorim periodicaabec

 

cinahl citefactor cuidenplusb socolar ulrichs sumarios