Podcast | The first cases of HIV cure in a socioanthropological approach
DOI:
https://doi.org/10.51359/2526-3781.2024.260576Keywords:
HIV, Hematopoietic Stem Cell Transplantation, Cure, Biomedical Technology, Anthropology of Science and Technology, Medical AnthropologyAbstract
In this podcast, I talk about a challenging topic in the field of medical science: the cure for HIV. The main objective is to discuss, from a socioanthropological perspective and using accessible language, the first five cases of "cure" or "long-term remission" of HIV. These recent and unprecedented results in the history of medicine were achieved through experimental stem cell transplants, where donors had a genetic mutation inherited from both parents (CCR5Δ32/Δ32), providing "natural resistance" to virus infection. Furthermore, throughout the podcast, I talk about the virus's mechanisms in the human body, available treatments, genetic considerations, the role of hope in this context, and, in a more comprehensive sense, I refer to it as the "political economy of HIV cure”. The stories and discussions I share here are based on my doctoral dissertation, titled “Transplanting hope”: Technobiopolitics in Experimental Stem Cell Therapies for HIV Cure, developed in the Graduate Program in Social Sciences at the Institute of Philosophy and Human Sciences (IFCH) of the State University of Campinas (Unicamp), Brazil, supervised by Prof. Dr. Daniela Tonelli Manica.
References
ALLERS, Kristina; HÜTTER, Gero; HOFMANN, Jörg; LODDENKEMPER, Christoph; RIEGER, Kathrin; THIEL, Eckhard; SCHNEIDER, Thomas. Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation. Blood, v. 117, n. 10, p. 2791–2799, 2011. DOI: 10.1182/blood-2010-09-309591.
BROWN, Nik. Hope Against Hype - Accountability in Biopasts, Presents and Futures. Science & Technology Studies, v. 16, n. 2, p. 3–21, 2003. DOI: 10.23987/sts.55152.
BROWN, Nik. Shifting Tenses: Reconnecting Regimes of Truth and Hope. Configurations, v. 13, n. 3, p. 331–355, 2005. DOI: 10.1353/con.2007.0019.
BROWN, Timothy Ray. I Am the Berlin Patient: A Personal Reflection. AIDS Research and Human Retroviruses, Las Vegas, Nevada, v. 31, n. 1, p. 2–3, 2015. DOI: 10.1089/aid.2014.0224.
DEEKS, Steven G. et al. Research priorities for an HIV cure: International AIDS Society Global Scientific Strategy 2021. Nature Medicine, v. 27, n. 12, p. 2085–2098, 2021. DOI: 10.1038/s41591-021-01590-5.
DELVECCHIO GOOD, Mary-Jo; GOOD, Byron J.; SCHAFFER, Cynthia; LIND, Stuart E. American oncology and the discourse on hope. Culture, Medicine and Psychiatry, v. 14, n. 1, p. 59–79, 1990. DOI: 10.1007/BF00046704.
DICKTER, Jana et al. The “City of Hope” Patient: prolonged HIV-1 remission without antiretrovirals (ART) after allogeneic hematopoietic stem cell transplantation (aHCT) of CCR5-Δ32/Δ32 donor cells for acute myelogenous leukemia (AML). In: 24TH INTERNATIONAL AIDS CONFERENCE 2022, Montreal, Canadá. Anais [...]. Montreal, Canadá p. abstract 12508. Disponível em: https://programme.aids2022.org/Abstract/Abstract/?abstractid=12508. Acesso em: 22 ago. 2022.
DYBUL, Mark et al. The case for an HIV cure and how to get there. The Lancet HIV, v. 8, n. 1, p. e51–e58, 2021. DOI: 10.1016/S2352-3018(20)30232-0.
FRANKLIN, Sarah. Biological Relatives: IVF, Stem Cells, and the Future of Kinship. Durham and London: Duke University Press, 2013.
GUPTA, Ravindra K. et al. Evidence for HIV-1 cure after CCR5Δ32/Δ32 allogeneic haemopoietic stem-cell transplantation 30 months post analytical treatment interruption: a case report. The Lancet HIV, v. 7, n. 5, p. e340–e347, 2020. DOI: 10.1016/S2352-3018(20)30069-2.
HIGHLEYMAN, Liz. Coming Out as Cured. 2023. Disponível em: https://www.poz.com/article/coming-cured. Acesso em: 18 maio. 2023.
HSU, Jingmei et al. HIV-1 remission and possible cure in a woman after haplo-cord blood transplant. Cell, v. 186, n. 6, p. 1115- 1126.e8, 2023. DOI: 10.1016/j.cell.2023.02.030.
JENSEN, Björn-Erik Ole et al. In-depth virological and immunological characterization of HIV-1 cure after CCR5Δ32/Δ32 allogeneic hematopoietic stem cell transplantation. Nature Medicine, 2023. DOI: 10.1038/s41591-023-02213-x.
JOHNSON, Mark. After decades under a virus’s shadow, he now lives free of HIV. 2023. Disponível em: https://www.washingtonpost.com/science/2023/04/03/hiv-remission-blood-stem-cell-transplant/. Acesso em: 21 abr. 2023.
MANDAVILLI, Apoorva. The “London Patient”, Cured of H.I.V., Reveals His Identity. The New York Times, New York, 2020. Disponível em: https://www.nytimes.com/2020/03/09/health/hiv-aids-london-patient-castillejo.html. Acesso em: 21 out. 2020.
MOREIRA, Tiago; PALLADINO, Paolo. Between truth and hope: on Parkinson’s disease, neurotransplantation and the production of the ‘self’. History of the Human Sciences, v. 18, n. 3, p. 55–82, 2005. DOI: 10.1177/0952695105059306.
NOVAS, Carlos. The Political Economy of Hope: Patients’ Organizations, Science and Biovalue. BioSocieties, v. 1, n. 3, p. 289–305, 2006. DOI: 10.1017/S1745855206003024.
OLIVEIRA, Kris Herik De. “Transplantando esperança”: tecnobiopolítica em terapias exeprimentais com células-tronco para a cura do HIV. 2023. 490 f. Tese (Doutorado em Ciências Sociais) - Universidade Estadual de Campinas, Instituto de Filosofia e Ciências Humanas, Programa de Pós-graduação em Ciências Sociais, Campinas, SP, 2023. Disponível em: https://hdl.handle.net/20.500.12733/13887. Acesso em: 6 dez. 2023.
ROSE, Nikolas. A política da própria vida: biomedicina, poder e subjetividade no século XXI. São Paulo: Paulus, 2013.
UNAIDS, Programa Conjunto das Nações Unidas sobre HIV/Aids. Fact sheet - Latest global and regional statistics on the status of the AIDS epidemic. UNAIDS, 2023. Disponível em: https://www.unaids.org/en/resources/documents/2023/UNAIDS_FactSheet.
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