Serum creatinine levels and funtional capacity in pacients after covid-19 infection: Cross-sectional study
Keywords:
SARS-CoV-2 infection, acute kidney injury, physical functional performance, walk test, muscle strengthAbstract
Introduction: Covid-19 can develop a multisystemic inflammatory syndrome and cause damages in the renal system. Among the aggravating factors, the presence of serum creatinine changes has been associated with acute kidney injury. And because it is an inflammatory and protein-muscle metabolism marker the aggressions to the muscles contribute to the elevation of serum creatinine, which has been evidenced in the presence of higher morbidity and mortality. These factors have repercussions on muscle function and functional capacity after Covid-19.
Objective: To assess serum creatinine levels and functional capacity in patients after Covid-19.
Method: Cross-sectional study, developed from March to September 2021 in the post-intensive care unit of a university hospital and approved by the institutional ethics committee (No. 4,590,736). Men and women aged 35-75 years, laboratory confirmation of Covid-19 and creatinine results were included. Sociodemographic (age, gender), anthropometric [weight, height, body mass index (BMI)], clinical (comorbidities) and functional (six-minute walk test and grip strength) data were characterized.
Results: 37 patients, mean age 56.61 ±10.04 years, 85.97 ±23.05 kg, 1.60 ±1.60 m and BMI of 32.99 ±32.57 kg/m2 (obese and overweight in 73.8% of the sample). 21.6% of the sample had elevated serum creatinine. The performance in the walking test and grip strength of men and women were 346.58 ±130.99m (69.76% predicted) and 300 ±125.09m (64.27% predicted), and 29.88 ±11.67kgf (51.9% predicted) and 24.02 ±11.67kgf (48.1% predicted) respectively.
Conclusion: Critically ill individuals who required hospitalization after Covid-19 infection desenvolved elevated serum creatinine levels and reduced functional capacity.
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